Alzheimer’s Disease ACE Simulator

  • Webinars

    Webinar

    Predicting Alzheimer’s Disease Progression Using Archimedes Condition Event (ACE) Simulation

    Presenters: Anuraag Kansal, PhD, Senior Research Scientist, Modeling and Simulation, and Director, Disease Simulation, Evidera; K. Jack Ishak, PhD, Senior Research Leader, Executive Director, Center of Excellence for Statistics, Evidera

    Additional Info
    Contact us for slides
    Recording
  • Presentations

    Poster

    PRM80: Improving Precision by Applying Disease Progression Equations from Multiple Sources in the Alzheimer's Disease Archimedes Condition Event (ACE) Simulator

    ISPOR 21st Annual International Meeting – 2016:

    Washington, DC, USA
    21-May-2016

    Authors/Presenters: Tafazzoli A, Dos Santos R, Ishak J, Krotneva M, Kansal A

    Year: 2016

    View

    Poster

    PRM84: Structural Sensitivity Analyses of Mortality and Location of Care in a Simulation of Alzheimer's Disease

    ISPOR 21st Annual International Meeting – 2016:

    Washington, DC, USA
    21-May-2016

    Authors/Presenters: Kansal A, Dos Santos R, Tafazzoli A

    Year: 2016

    View

    Poster

    PRM82: The Evolution of Economic Modeling in Alzheimer's Disease: Where Do We Go From Here?

    ISPOR 21st Annual International Meeting – 2016:

    Washington, DC, USA
    21-May-2016

    Authors/Presenters: Hernandez L

    Year: 2016

    View
  • Fact Sheets

    Fact Sheet

    Alzheimer’s Disease ACE Simulator
    Download

    Fact Sheet

    Alzheimer’s Disease ACE Simulator Q&A
    Download

    Fact Sheet

    Modeling & Simulation
    Download

    Fact Sheet

    Cognitive Impairment & Alzheimer’s Disease Experience Summary
    Download

Building on its widely used models in Alzheimer’s Disease (AD), Evidera scientists designed the AD ACE to assess interventions that may cover from the earliest (i.e., mild cognitive impairment or prodromal AD) through the most severe stages of the disease, as well as the transition from normal cognitive function. ACE simulators are comprehensive, extensively documented, multi-application disease-specific models designed to support commercial strategy development, inform clinical trial designs, and meet HTA agency requirements for formal submissions. The AD ACE addresses the complex interactions between multiple components of AD pathology (e.g., biomarkers, cognition, behavior, function) and their role in disease progression.  It also fully considers interrelated clinical, epidemiologic and economic outcomes, providing a platform that allows for rapid incorporation of intervention-specific data.

ACE diagram-15oct2015

As the AD ACE is programmed in MS Excel®, it does not require any additional software and it is very transparent, a key feature for HTA bodies, decision makers, and internal stakeholders.  In addition, it is readily modified to address the specific features of the therapy or diagnostic that’s being studied.

A summary of Evidera’s economic modeling experience in cognitive impairment and AD is available here.

A list of Evidera’s publications, presentations, webinars, and white papers in AD is available here.

Alzheimer's Disease Experts

  • Webinars

    Webinar

    Predicting Alzheimer’s Disease Progression Using Archimedes Condition Event (ACE) Simulation

    Presenters: Anuraag Kansal, PhD, Senior Research Scientist, Modeling and Simulation, and Director, Disease Simulation, Evidera; K. Jack Ishak, PhD, Senior Research Leader, Executive Director, Center of Excellence for Statistics, Evidera

    Additional Info
    Contact us for slides
    Recording
  • Presentations

    Poster

    PRM80: Improving Precision by Applying Disease Progression Equations from Multiple Sources in the Alzheimer's Disease Archimedes Condition Event (ACE) Simulator

    ISPOR 21st Annual International Meeting – 2016:

    Washington, DC, USA
    21-May-2016

    Authors/Presenters: Tafazzoli A, Dos Santos R, Ishak J, Krotneva M, Kansal A

    Year: 2016

    View

    Poster

    PRM84: Structural Sensitivity Analyses of Mortality and Location of Care in a Simulation of Alzheimer's Disease

    ISPOR 21st Annual International Meeting – 2016:

    Washington, DC, USA
    21-May-2016

    Authors/Presenters: Kansal A, Dos Santos R, Tafazzoli A

    Year: 2016

    View

    Poster

    PRM82: The Evolution of Economic Modeling in Alzheimer's Disease: Where Do We Go From Here?

    ISPOR 21st Annual International Meeting – 2016:

    Washington, DC, USA
    21-May-2016

    Authors/Presenters: Hernandez L

    Year: 2016

    View
  • Fact Sheets

    Fact Sheet

    Alzheimer’s Disease ACE Simulator
    Download

    Fact Sheet

    Alzheimer’s Disease ACE Simulator Q&A
    Download

    Fact Sheet

    Modeling & Simulation
    Download

    Fact Sheet

    Cognitive Impairment & Alzheimer’s Disease Experience Summary
    Download
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