Meta Research

Unlock the value of published and “grey” literature to build your foundation of evidence.

Services & Products

  • Publications

    Publication

    Characteristics and Medication Use of Psoriasis Patients Who May or May Not Qualify for Randomized Controlled Trials. J Manag Care Spec Pharm. 2017 Mar;23(3):370-381. doi: 10.18553/jmcp.2017.16367. Epub 2017 Jan 31. ABSTRACT

    Publication

    Systematic Review and Mixed Treatment Comparison Meta-analysis of Randomized Clinical Trials of Primary Oral Antifungal Prophylaxis in Allogeneic Hematopoietic Cell Transplant Recipients. BMC Infect Dis. 2015 Dec;15(1):855. Epub 2015 Mar 17. ABSTRACT

    Publication

    An Evaluation of Variation in Published Estimates of Schizophrenia Prevalence from 1990-2013: A Systematic Literature Review. BMC Psychiatry. 2015 Aug 12;15:193. ABSTRACT
    See More
  • Webinars

    Webinar

    Network Meta-Analyses and Indirect Treatment Comparisons – Not Just for Reimbursement

    Presenters: Yingxin Xu, PharmD, PhD, Research Scientist, Meta Research, Evidera; Kyle Fahrbach, PhD, Senior Biostatistician, Meta Research, Evidera; Maria Rizzo, MSc, Senior Research Associate, Meta Research, Evidera

    Additional Info
    Contact us for slides

    Webinar

    Indirect Treatment Comparison without Network Meta-Analysis: An Overview of Simulated Treatment Comparison (STC) and Matching Adjusted Indirect Comparison (MAIC)

    Presenters: K. Jack Ishak, PhD, Senior Research Leader, and Executive Director, Center of Excellence - Statistics, Evidera

    Additional Info
    Contact us for slides
    See More
  • White Papers

    Whitepaper

    Challenges in Network Meta-Analyses of Oncology

    Authors: Yingxin Xu, PharmD, PhD, Evidera; Ajibade Ashaye, MD, MPH, Evidera; Kyle Fahrbach, PhD, Evidera

    Year: 2016

    View

    Whitepaper

    Early Network Meta-Analyses (NMAs): Filling a Need in Clinical Trial Designs and HTA Submissions

    Authors: Yingxin Xu, PharmD, PhD, Research Scientist, Meta Research, Evidera; Kyle Fahrbach, PhD, Senior Biostatistician, Meta Research, Evidera; Floortje van Nooten, MSc, Director HEOR, Astellas; Grace Jennings, PhD, Technical Advisor, Scientific Advice, NICE

    Year: 2015

    View

    Whitepaper

    What's in a Name? Systematic and Non-Systematic Literature Reviews, and Why the Distinction Matters

    Authors: Rachel Huelin, Director and Research Scientist, Meta Research; Ike Iheanacho, MBBS, Director and Research Scientist, Meta Research; Krista Payne, MEd, Executive Director, Evidence Strategy Solutions; Karen Sandman, PhD, U.S. Practice Lead, Payer Communications

    Year: 2015

    View
    See More
  • Presentations

    Poster

    Moving Beyond the PICOS: Appropriate Comparative Observational Data Selection Can Facilitate Meta-Analysis of Relative Treatment Effects

    ISPOR 18th Annual European Congress – 2015:

    Milan, Italy
    07-Nov-2015

    Authors/Presenters: Sallum R, Zhang Y, Xu Y

    Year: 2015

    View

    Poster

    Impact of Change in Lung Function and COPD-related Patient Outcomes on Exacerbations and Hospitalizations: A Systematic Literature Review

    ISPOR 20th Annual International Meeting – 2015:

    Philadelphia, PA, USA
    16-May-2015

    Authors/Presenters: Donohue JF, Marvel J, Martin AL, Travers KU, Cadarette S, Wilcox TK

    Year: 2015

    Poster

    The Legal and Ethical Implications of Using Data from Social Media Websites

    ISPOR 17th Annual European Congress – 2014:

    Amsterdam, Netherlands
    08-Nov-2014

    Authors/Presenters: Khankhel Z, Abogunrin S, Martin A

    Year: 2014

    View
    See More
  • Fact Sheets

    Fact Sheet

    Meta Research
    Download

Thoroughly mining the existing scientific evidence is a critical first step for your product development program. Evidera’s team of researchers has decades of experience in evidence review and synthesis, from the most basic literature reviews to cutting-edge and complex methods that can extract useful information from even the most disparate sources. We publish our studies regularly and have completed 30+ studies that have been incorporated into regulatory or HTA submissions. We have also completed at least 20 literature reviews in nearly every major therapeutic area, including 70+ reviews in oncology, 50+ in neurology and 40+ in cardiovascular.

Evidera will help you gain an understanding and unlock the value of published and “grey” literature to:

  • Capitalize on existing research while assessing evidence gaps
  • Support planning for evidence development
  • Derive inputs for economic modeling for HTA submissions
  • Inform study design and planning for primary research (e.g., selection of clinical efficacy endpoints or comparators) to facilitate future meta-analyses
  • Estimate comparative effects versus competitors when direct head-to-head data are not available
  • Quantify the reported burden-of-illness for dossiers and payer submissions
  • Detect early warnings of adverse events associated with a product

Any of these tasks can be part of an ongoing “surveillance” of the literature.

Offerings

Network Meta-Analysis

Understand the relative effectiveness of a product or treatment via a quantitative assessment of the available literature.

Literature Reviews

Understand clinical, epidemiological and/or health economic evidence via a systematic or targeted qualitative review of the available literature.

Evidence Surveillance and Social Media Review

Understand real-world outcomes by reviewing information from various social media sources, pharmacovigilance feeds, market intelligence updates, etc.

Evidence Mapping

Facilitate more efficient literature searching by mapping themes in existing literature.

Rapid Literature Reviews

Conduct fast, focused epidemiology and safety literature reviews to meet internal/external evidence needs in just days.

Novel Approaches to Indirect Comparison: Simulated Treatment Comparisons (STC) and Matching-Adjusted Indirect Comparisons (MAIC)

Use targeted comparisons to overcome challenges of traditional methods for indirect treatment comparison without compromising validity of results. Click here for more info.

Meta Research Experts

Services & Products

  • Publications

    Publication

    Characteristics and Medication Use of Psoriasis Patients Who May or May Not Qualify for Randomized Controlled Trials. J Manag Care Spec Pharm. 2017 Mar;23(3):370-381. doi: 10.18553/jmcp.2017.16367. Epub 2017 Jan 31. ABSTRACT

    Publication

    Systematic Review and Mixed Treatment Comparison Meta-analysis of Randomized Clinical Trials of Primary Oral Antifungal Prophylaxis in Allogeneic Hematopoietic Cell Transplant Recipients. BMC Infect Dis. 2015 Dec;15(1):855. Epub 2015 Mar 17. ABSTRACT

    Publication

    An Evaluation of Variation in Published Estimates of Schizophrenia Prevalence from 1990-2013: A Systematic Literature Review. BMC Psychiatry. 2015 Aug 12;15:193. ABSTRACT
    See More
  • Webinars

    Webinar

    Network Meta-Analyses and Indirect Treatment Comparisons – Not Just for Reimbursement

    Presenters: Yingxin Xu, PharmD, PhD, Research Scientist, Meta Research, Evidera; Kyle Fahrbach, PhD, Senior Biostatistician, Meta Research, Evidera; Maria Rizzo, MSc, Senior Research Associate, Meta Research, Evidera

    Additional Info
    Contact us for slides

    Webinar

    Indirect Treatment Comparison without Network Meta-Analysis: An Overview of Simulated Treatment Comparison (STC) and Matching Adjusted Indirect Comparison (MAIC)

    Presenters: K. Jack Ishak, PhD, Senior Research Leader, and Executive Director, Center of Excellence - Statistics, Evidera

    Additional Info
    Contact us for slides
    See More
  • White Papers

    Whitepaper

    Challenges in Network Meta-Analyses of Oncology

    Authors: Yingxin Xu, PharmD, PhD, Evidera; Ajibade Ashaye, MD, MPH, Evidera; Kyle Fahrbach, PhD, Evidera

    Year: 2016

    View

    Whitepaper

    Early Network Meta-Analyses (NMAs): Filling a Need in Clinical Trial Designs and HTA Submissions

    Authors: Yingxin Xu, PharmD, PhD, Research Scientist, Meta Research, Evidera; Kyle Fahrbach, PhD, Senior Biostatistician, Meta Research, Evidera; Floortje van Nooten, MSc, Director HEOR, Astellas; Grace Jennings, PhD, Technical Advisor, Scientific Advice, NICE

    Year: 2015

    View

    Whitepaper

    What's in a Name? Systematic and Non-Systematic Literature Reviews, and Why the Distinction Matters

    Authors: Rachel Huelin, Director and Research Scientist, Meta Research; Ike Iheanacho, MBBS, Director and Research Scientist, Meta Research; Krista Payne, MEd, Executive Director, Evidence Strategy Solutions; Karen Sandman, PhD, U.S. Practice Lead, Payer Communications

    Year: 2015

    View
    See More
  • Presentations

    Poster

    Moving Beyond the PICOS: Appropriate Comparative Observational Data Selection Can Facilitate Meta-Analysis of Relative Treatment Effects

    ISPOR 18th Annual European Congress – 2015:

    Milan, Italy
    07-Nov-2015

    Authors/Presenters: Sallum R, Zhang Y, Xu Y

    Year: 2015

    View

    Poster

    Impact of Change in Lung Function and COPD-related Patient Outcomes on Exacerbations and Hospitalizations: A Systematic Literature Review

    ISPOR 20th Annual International Meeting – 2015:

    Philadelphia, PA, USA
    16-May-2015

    Authors/Presenters: Donohue JF, Marvel J, Martin AL, Travers KU, Cadarette S, Wilcox TK

    Year: 2015

    Poster

    The Legal and Ethical Implications of Using Data from Social Media Websites

    ISPOR 17th Annual European Congress – 2014:

    Amsterdam, Netherlands
    08-Nov-2014

    Authors/Presenters: Khankhel Z, Abogunrin S, Martin A

    Year: 2014

    View
    See More
  • Fact Sheets

    Fact Sheet

    Meta Research
    Download
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