Comparative clinical benefit assessments are at the core of Health Technology Assessments (HTAs) in Europe. HTAs are a multi-disciplinary process considering input and evidence from medical, social, and economic sources. They are used to inform the design of health policies that allow the safe and effective use of new technologies within individual health systems and their specific conditions. Currently, HTAs are conducted separately by individual European countries, however, on 3 April 2018, EU country parliaments adopted the European Commission’s (EC) new Directive (2018/0018) which outlines several activities required for a European Health Technology Assessment (EU HTA).