On December 23, 2019, the Academy of Managed Care Pharmacy (AMCP) released Version 4.1 of the AMCP Format for Formulary Submissions. This new version of the AMCP Format describes three types of dossiers that manufacturers may choose to develop: Unapproved Product Dossiers, Approved Product Dossiers, and Unapproved Use Dossiers. Our white paper focuses on the process of converting an existing Post-Approval Dossier that follows Version 4.0 of the AMCP Format into an Approved Product Dossier that follows Version 4.1 of the AMCP Format for Unapproved Product Dossiers and Unapproved Use Dossiers.