Simulated treatment comparisons (STC) & Matching Adjusted Indirect Comparisons (MAIC)

Targeted Approaches to Enhance Indirect Comparisons

  • Publications

    Publication

    Simulation and Matching-Based Approaches for Indirect Comparison of Treatments. Pharmacoeconomics. 2015 Jun;33(6):537-49. doi: 10.1007/s40273-015-0271-1. ABSTRACT

    Publication

    No Head-to-Head Trial? Simulate the Missing Arms. Pharmacoeconomics. 2010 Oct 1; 28(10):957-967. ABSTRACT

    Publication

    Adjusting for Patient Crossover in Clinical Trials Using External Data: A Case Study of Lenalidomide for Advanced Multiple Myeloma. Value Health. 2011 Jul-Aug; 14(5):672-678. ABSTRACT
  • Webinars

    Webinar

    Indirect Treatment Comparison without Network Meta-Analysis: An Overview of Simulated Treatment Comparison (STC) and Matching Adjusted Indirect Comparison (MAIC)

    Presenters: K. Jack Ishak, PhD, Senior Research Leader, and Executive Director, Center of Excellence - Statistics, Evidera

    Additional Info
    Contact us for slides
  • Presentations

    Poster

    PRM196: Indirect Treatment Comparisons with Guided Matching-Based Adjustment: A Hybrid of the STC and MAIC Techniques

    ISPOR 21st Annual International Meeting – 2016:

    Washington, DC, USA
    21-May-2016

    Authors/Presenters: Ishak KJ, Rael M, Proskorovsky I

    Year: 2016

    View

    Workshop

    Making Sense of Novel Approaches for Indirect Comparison: Similarities and Differences of Simulation and Matching Based Approaches

    ISPOR 18th Annual European Congress – 2015:

    Milan, Italy
    07-Nov-2015

    Authors/Presenters: Ishak KJ, Phatak H, Masseria C

    Year: 2015

    Poster

    Simulated Treatment Comparison of Time-To-Event (and other Non-Linear) Outcomes

    ISPOR 18th Annual European Congress – 2015:

    Milan, Italy
    07-Nov-2015

    Authors/Presenters: Ishak KJ, Rael M, Phatak H, Masseria C, Lanitis T

    Year: 2015

    See More
  • Fact Sheets

    Fact Sheet

    STC & MAIC
    Download

Evidence on the relative effectiveness of treatments is rarely available from head-to-head studies, and as a result published results from clinical trials must often be used for indirect comparisons via network meta-analysis (NMA). Although often very effective, NMA may be challenging if there is an incomplete or disjointed evidence network, or substantial heterogeneity between studies, or when key treatments to be compared are separated by multiple intermediate steps or linking comparisons within the network. STC and MAIC can often help to overcome these challenges, and may also provide additional depth and a different perspective when challenges do not exist. Submissions to health authorities have successfully employed these methods, and they may be required in the future.

STC MAIC Diagram-01

Evidera’s team of statisticians and modelers are innovators in alternative approaches to indirect comparison, with publications in this area for over five years. We have successfully supported National Institute for Health and Care Excellence (NICE) submissions where targeted approaches have been applied for indirect comparisons. We are able to leverage world-class health economics, modeling and literature review teams for scientific and strategic support in assessing the need and suitability of targeted comparison, skillfully executing the analyses, clearly communicating the findings, and incorporating these into health economic assessments and agency submissions.

  • Publications

    Publication

    Simulation and Matching-Based Approaches for Indirect Comparison of Treatments. Pharmacoeconomics. 2015 Jun;33(6):537-49. doi: 10.1007/s40273-015-0271-1. ABSTRACT

    Publication

    No Head-to-Head Trial? Simulate the Missing Arms. Pharmacoeconomics. 2010 Oct 1; 28(10):957-967. ABSTRACT

    Publication

    Adjusting for Patient Crossover in Clinical Trials Using External Data: A Case Study of Lenalidomide for Advanced Multiple Myeloma. Value Health. 2011 Jul-Aug; 14(5):672-678. ABSTRACT
  • Webinars

    Webinar

    Indirect Treatment Comparison without Network Meta-Analysis: An Overview of Simulated Treatment Comparison (STC) and Matching Adjusted Indirect Comparison (MAIC)

    Presenters: K. Jack Ishak, PhD, Senior Research Leader, and Executive Director, Center of Excellence - Statistics, Evidera

    Additional Info
    Contact us for slides
  • Presentations

    Poster

    PRM196: Indirect Treatment Comparisons with Guided Matching-Based Adjustment: A Hybrid of the STC and MAIC Techniques

    ISPOR 21st Annual International Meeting – 2016:

    Washington, DC, USA
    21-May-2016

    Authors/Presenters: Ishak KJ, Rael M, Proskorovsky I

    Year: 2016

    View

    Workshop

    Making Sense of Novel Approaches for Indirect Comparison: Similarities and Differences of Simulation and Matching Based Approaches

    ISPOR 18th Annual European Congress – 2015:

    Milan, Italy
    07-Nov-2015

    Authors/Presenters: Ishak KJ, Phatak H, Masseria C

    Year: 2015

    Poster

    Simulated Treatment Comparison of Time-To-Event (and other Non-Linear) Outcomes

    ISPOR 18th Annual European Congress – 2015:

    Milan, Italy
    07-Nov-2015

    Authors/Presenters: Ishak KJ, Rael M, Phatak H, Masseria C, Lanitis T

    Year: 2015

    See More
  • Fact Sheets

    Fact Sheet

    STC & MAIC
    Download
Back to Top